Tuesday, February 26, 2008

Neuropsychology Abstract of the Day: Mild Cognitive Impairment (MCI)

Karas G, Sluimer J, Goekoop R, van der Flier W, Rombouts S, Vrenken H, Scheltens P, Fox N, & Barkhof F. Amnestic Mild Cognitive Impairment: Structural MR Imaging Findings Predictive of Conversion to Alzheimer Disease. American Journal of Neuroradiology. 2008 Feb 22 [Epub ahead of print].

Department of Diagnostic Radiology, Image Analysis Center, Alzheimer Center, and Department of Clinical Neurology, VU University Medical Center, Amsterdam, the Netherlands; Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, London, UK; Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center and Leiden Institute for Brain and Cognition, Leiden, the Netherlands; Department of Psychology, Leiden University, Leiden, the Netherlands; and Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.

BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) is considered by many to be a prodromal phase of Alzheimer disease (AD). We used voxel-based morphometry (VBM) to find out whether structural differences on MR imaging could offer insight into the development of clinical AD in patients with amnestic MCI at 3-year follow-up. MATERIALS AND METHODS: Twenty-four amnestic patients with MCI were included. After 3 years, 46% had progressed to AD (n = 11; age, 72.7 +/- 4.8 years; women/men, 8/3). For 13 patients (age, 72.4 +/- 8.6 years; women/men, 10/3), the diagnosis remained MCI. Baseline MR imaging at 1.5T included a coronal heavily T1-weighted 3D gradient-echo sequence. Localized gray matter differences were assessed with VBM. RESULTS: The converters had less gray matter volume in medial (including the hippocampus) and lateral temporal lobe, parietal lobe, and lateral temporal lobe structures. After correction for age, sex, total gray matter volume, and neuropsychological evaluation, left-sided atrophy remained statistically significant. Specifically, converters had more left parietal atrophy (angular gyrus and inferior parietal lobule) and left lateral temporal lobe atrophy (superior and middle temporal gyrus) than stable patients with MCI. CONCLUSION: By studying 2 MCI populations, converters versus nonconverters, we found atrophy beyond the medial temporal lobe to be characteristic of patients with MCI who will progress to dementia. Atrophy of structures such as the left lateral temporal lobe and left parietal cortex may independently predict conversion.

PMID: 18296551 [PubMed - as supplied by publisher]

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3 Comments:

Anonymous jace said...

Thought your readers may be interested in a mental health campaign I'm helping to start called everyminute.org that is fighting stigma in trying to organize a grassroots lobbying force to secure more research funding. We just launched our website last week at http://www.everyminute.org Please check it out if it sounds interesting to you. Thanks!
Jace

4:29 PM  
Blogger Bree said...

Hey I started a TBI blog about my experiences when I was kicked in the head by a horse in July of 2005 and was in a coma. Its a good story and I hope to help other TBI victims realize they are not alone in their struggles.

7:27 PM  
Anonymous http://psikolibro.blogspot.com/2007/11/libros-gratis.html said...

Descarga libros gratis en la Web Oficial de Psikolibro


http://psikolibro.blogspot.com/2007/11/libros-gratis.html



Ademas hay cientos de libros gratis de psicologia y ciencias sociales.
Para acceder a ellos, solo debes ingresar a los indices tematicos o
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Actualizacion

C. G. Jung y Otros - Encuentro con la Sombra
Umberto Eco - Como Se Hace Una Tesis
Zbigniew Brzezinski - La Era Tecnotronica
Hans Georg Gadamer - Verdad y Metodo II
Theodor Adorno y Max Horkheimer - Lecciones de Sociologia


Saludos
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12:18 AM  

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